Search Results for: Research
Andrea Fuso, PhD, a 15-year research collaborator with focusing on cognitive health, has expanded his area of study to include Vitamin K2 in neurological support and has published highlighting K2’s role in neurological protection.
Recent research highlights the potential role of vitamin K2 in delaying cognitive decline. Our latest brochure explores how vitamin K2 can support brain health.
Maintaining a balance between physical and cognitive health is crucial for overall well-being. As we age, it’s essential to maintain not just our bodies but also our minds. The Natural Products industry is increasingly focusing on cognitive health, making this a perfect time to highlight the potential of vitamin K2 in supporting brain health.
The Relationship Between Vitamin K2 and Cognition
MenaQ7® research highlights vitamin K2’s ability to modulate oxidative stress, inflammation, and vascular stiffness, all conditions that can negatively impact our cognitive health. At the same time, MenaQ7® activates vitamin K-dependent proteins and supports mitochondrial function, positively affecting it. Simply put, Vitamin K2 ignites processes in the body that support a healthy brain.
Supporting Brain Health by Supporting Heart Health
MenaQ7® Vitamin K2 is clinically proven to enhance heart health by increasing arterial elasticity and reducing arterial stiffness. Studies show that arterial calcification and arterial stiffness increase the risk of dementia and cognitive impairment. This compelling connection places vitamin K2 at the center of the Heart-Brain Connection.
Vitamin K2 for A Sharper and Happier Mind
As we age, maintaining strong bones and a healthy cardiovascular system is critical, as is preserving cognitive acuity. MenaQ7® is the only clinically proven vitamin K2 as MK-7 supporting cardiovascular and bone health. An upcoming clinical study will test MenaQ7®’s effectiveness in reducing migraine attacks, a condition linked to arterial stiffness. The results could position vitamin K2 as a complete and all-round nutrient for healthy aging.
> Gain more in the brochure “VITAMIN K2 IN MOOD AND COGNITIVE”
LEGAL INFORMATION AND GENERAL CONDITIONS OF USE FOR THE www.menaq7.com WEBSITE Date of last update: May 7th, 2024 PUBLISHER Gnosis by Lesaffre, legal form, registered under N° LESAFFRE ET COMPAGNIE (LESAFFRE & CIE): RCS Paris B 316 055 672 with the capital of EUR [734,500.00] Trade and Companies Register, with its registered office at 41 … Continue reading Legal Notices
LEGAL INFORMATION AND GENERAL CONDITIONS OF USE FOR THE www.menaq7.com WEBSITE
Date of last update: May 7th, 2024
PUBLISHER
Gnosis by Lesaffre, legal form, registered under N° LESAFFRE ET COMPAGNIE (LESAFFRE & CIE): RCS Paris B 316 055 672 with the capital of EUR [734,500.00] Trade and Companies Register, with its registered office at 41 Rue Etienne Marcel – 75001 PARIS. “Lesaffre”
CONTACT
Administrative headquarters
137, Rue Gabriel Péri
F-59700 Marcq-en-Baroeul
Telephone: 00 33 +(0)3 20 81 61 00
GENERAL TERMS AND CONDITIONS OF USE
Lesaffre, publishes the website accessible at the URL address www.menaq7.com (hereinafter referred to as “the Site”) in order to provide general information on the activities of MenaQ7 from Gnosis by Lesaffre.
Within the meaning of these General Conditions of Use (hereinafter referred to as the “GCU”), the Lesaffre Group (hereinafter referred to as the “Lesaffre Group”) refers to the group made up of the company Lesaffre et Compagnie, a public limited company with a Board of Directors, registered under the SIRET number 31605567200018 in the Paris Trade and Companies Register, whose registered office is located at 41 rue Etienne Marcel, 75001 PARIS, as well as its subsidiaries, regardless of where they are established. In terms of shareholdings, control of companies and dominant influence, all companies meeting the criteria set out in Articles L233-1 to L233-3 and L233-16 of the French Commercial Code are defined under the terms of this article.
The purpose hereof is to define the terms and conditions under which any person, regardless of the access device (computer, tablet, etc.), the type of connection (private connection, public Wifi, etc.) and the place of connection, may access and use the Site (hereinafter referred to as the “Users” or individually as the “User”).
ARTICLE 1 – DESCRIPTION OF THE SITE
1.1 The website provides information on Gnosis by Lesaffre, its activities, its mission and its business, as well as news.
1.2 The Site allows the User to:
Access the websites of the Lesaffre Group’s other subsidiaries and operational units dedicated to the business unit Gnosis by Lesaffre;
- Contact Lesaffre using the contact forms
- Subscribe to email newsletter administrated by Gnosis by Lesaffre
- Accept or decline cookie usage for various operational and marketing activities
- Download research and materials created by Gnosis by Lesaffre
1.3 Lesaffre may develop the functionalities of the site, without this giving rise to any right to compensation whatsoever for the benefit of the user. Users are therefore expressly informed that the availability of all or part of the functionalities is at the discretion of Lesaffre International.
ARTICLE 2 – TECHNICAL CONDITIONS FOR ACCESSING AND USING THE SITE
2.1 The Site is compatible with standard browsers on the market. It is the User’s responsibility to check that they are using a browser version that is up to date at the time of consulting the Site. Failure to do so may result in difficulties accessing or using the Site.
2.2 Any hardware and/or software required to access and/or use the Site is the sole responsibility of the User, who is solely liable for the proper functioning of his/her equipment and Internet access. It is the User’s responsibility to ensure that he/she has an Internet connection enabling him/her to use the Site. It is also the User’s responsibility to take all appropriate measures to protect his/her own data, computer systems and/or software from contamination by any viruses.
2.3 The User undertakes to check that the configuration of his/her browser and operating system allows him/her to access and consult the Site. The User is responsible for resolving any bugs affecting his/her browser and/or operating system. The same applies to the detection and management of any virus likely to affect their terminal.
2.4 The Site is accessible unless interrupted for maintenance and/or in the event of force majeure and/or in the event of the occurrence of an event beyond the control of Lesaffre International. Lesaffre may not be held liable in the absence of fault, in the event of the unavailability of the site, for whatever reason, and will do its utmost to re-establish the service.
ARTICLE 3 – ACCEPTANCE AND AMENDMENT OF THE GCU
3.1 Access to and use of the Site are subject to compliance with these GCU. Therefore, before consulting the Site, all Users must read the GCU, which are accessible from the Site’s home page and from each of its pages.
3.2 The GCU may be modified by Lesaffre in order to take into account, in particular, changes to the functionalities of the Site, as well as applicable regulations. Any new version of the GCU will be made available to Users on the Site. Users should therefore consult the GCUs on a regular basis.
ARTICLE 4 – OBLIGATIONS – LIABILITY
4.1 The User undertakes to use the Site in accordance with these GCU. By accessing and using the Site, the User undertakes in particular not to:
-
- any use of the Site that contravenes applicable laws and regulations or violates the rights of third parties;
- any action which may cause prejudice to Lesaffre, to one or more entities of the Lesaffre Group or to another User;
- harm, hinder or distort the proper functioning of the Site;
- to probe, scan, scrape or technically analyze the Site;
- to test the vulnerability, performance or functionality of the Site for any reason other than those necessary for its use;
- circumvent the measures implemented by Lesaffre to guarantee the security of the site.
4.2 The user expressly acknowledges that if he/she does not respect these General Conditions of Use, Lesaffre or any of the subsidiaries of the Lesaffre Group may not be held liable. On the contrary, the user may be required to compensate Lesaffre and/or one or more of the subsidiaries of the Lesaffre Group for any costs, disbursements or prejudice in the event of all or part of them being called into question by another user and/or by a third party for an act attributable to the user.
4.3 The site is provided “as is”. Given this state of affairs, which is recognized and accepted by the user, Lesaffre International cannot be held responsible for the temporary or definitive impossibility of the user accessing the site or all or part of the site’s functionalities. Lesaffre International’s obligation to supply is limited to an obligation of means. Lesaffre International does not guarantee the durability or performance of the functionalities accessible on the website.
4.4 Neither Lesaffre nor the user may be held liable in the event of force majeure as defined by the laws of the country where is located Lesaffre’s headquarter and the corresponding jurisprudence.
4.5 Lesaffre cannot be held responsible for the consequences:
- the fault or negligence of the User;
- use of the Site by the User that does not comply with these GCU and/or applicable regulations;
- fraudulent use of the site by third parties, in violation of the security measures implemented by Lesaffre.
4.6 Lesaffre declines all responsibility for indirect damage which, consequently, does not give rise to any right to compensation.
ARTICLE 5 – INTELLECTUAL PROPERTY
5.1 The Site and each of its components, including but not limited to texts, images, illustrations, photographs, databases, media, software, graphics, logos, icons, sounds, company names, trademarks, product models, drawings, animated sequences with or without sound, and other documentation, and more generally, all visual or sound elements (hereinafter the “Intellectual Property Elements”) are protected by intellectual property rights.
5.2 Lesaffre holds the intellectual property rights to the intellectual property elements. Some of the intellectual property elements may also be the property of third parties or other subsidiaries of the Lesaffre Group who have granted a license to Lesaffre in order to incorporate them directly or indirectly into the Site.
5.3 As a result, the user is forbidden to reproduce or represent elements of intellectual property without the authorization of Lesaffre International, as such reproduction and/or representation may constitute an act of counterfeiting.
5.4 Any authorization for the reproduction and representation of intellectual property elements must be requested by post from the following address: Lesaffre – Service Communication – 101 rue de Menin 59700 Marcq-en Baroeul, France.
ARTICLE 6 – HYPERTEXT LINKS
6.1 The Site may contain hypertext links referring the User to websites published by other subsidiaries of the Lesaffre Group. Lesaffre International declines all responsibility for access to, use of and content on these websites.
6.2 To find out about the conditions of use of websites published by other subsidiaries of the Lesaffre Group or by sites published by third parties to the Lesaffre Group to which the Site may refer, the User is invited to consult the websites concerned, as well as the general conditions of use of said sites.
ARTICLE 7 – CONTACT
For any questions or complaints relating to the site and/or the application of these GCU, users may contact Lesaffre – Service Communication – 101 rue de Menin 59700 Marcq-en-Baroeul, France.
ARTICLE 8 – MISCELLANEOUS
8.1 In the event that one of the clauses of these GCU is declared null and void or inapplicable by the effect of a law, regulation or court decision rendered by a competent court having the force of res judicata, the other clauses will retain their validity and force.
8.2 The fact that Lesaffre does not take advantage of a breach by one (or more) user(s) of any of the stipulations of these General Conditions of Use may not be interpreted as a tolerance or waiver on its part to take advantage of such a breach in the future.
ARTICLE 9 – APPLICABLE LAW
9.1 These GCU are governed by the laws of the country where is located Lesaffre’s headquarter.
9.2 In the event of a dispute, the Parties will use their best endeavours to reach an amicable solution before referring the matter to the Courts. However, if the amicable stage fails, the most diligent party will refer the matter to the competent court in accordance with the applicable legal provisions.
As we move through our adult years, sustaining an active lifestyle becomes increasingly vital. Key factors such as attaining peak bone mass and managing age-related arterial changes play significant roles in our overall health. Today, we consider aspects like physical energy and mental sharpness as essential components of our well-being. Here we explore how … Continue reading New Video:
Essentiel Role of MenaQ7® for Sport Performance
As we move through our adult years, sustaining an active lifestyle becomes increasingly vital. Key factors such as attaining peak bone mass and managing age-related arterial changes play significant roles in our overall health.
Today, we consider aspects like physical energy and mental sharpness as essential components of our well-being. Here we explore how MenaQ7® Vitamin K2 supports an active and healthy lifestyle.
Optimizing Bone Health and Strength
Maintaining bone strength after peak bone mass is reached around 30 is essential for an active life. This can be achieved through regular physical activity, like strength training and adequate nutrition. Vitamin K2 is crucial for directing calcium to bones, enhancing their strength and resilience. Research, including a 3-year study, has shown that a daily intake of 180 mcg of MenaQ7® Vitamin K2 can significantly improve bone mineral content, density, and strength.
Enhancing Cardiovascular Wellness
For sustaining physical activity, maintaining cardiovascular health is crucial. Healthy, flexible arteries ensure that blood flows efficiently, delivering nutrients to cells throughout the body. Lifestyle choices greatly influence this process. Supplementing with MenaQ7® Vitamin K2 has been proven to reduce arterial stiffness and improve elasticity, thereby supporting cardiovascular health and overall vitality.
Expanding Benefits Beyond Bone and Heart Health
While the benefits of MenaQ7® vitamin K2 for bone and heart health are well established, recent studies are exploring its potential effects on cognitive function, and MenaQ7® research highlights Vitamin K2’s role in managing oxidative stress and inflammation. Additionally, Vitamin K2 has been shown to increase ATP production and may support cognitive well-being, suggesting a holistic approach to a vibrant life.
Enjoy Vitamin K2 On-the-Go
While Vitamin K2 is nearly absent from most diets, supplementing has never been easier. MenaQ7® Vitamin K2 offers a convenient solution, fitting seamlessly into on-the-go formats like sports powders, drink mixes, and other tasty applications designed to support an active lifestyle.
> Learn more and watch the video “MENAQ7® FOR ACTIVE ADULTS”
Key moments from the Complementary Medicines Australia Innovation Day, featuring our essential ingredients, MenaQ7 as Vitamin K2 (MenaQ7®) and Active Folate (Quatrefolic®).
During the Complementary Medicines Australia (CMA) Innovation Day on May 7th, we were delighted to witness our key ingredients, Vitamin K2 (MenaQ7®) and Active Folate (Quatrefolic®), showcased prominently.
The event provided a valuable forum for industry professionals to share insights on manufacturing, formulation, ingredients, packaging, and innovation. Dr. Brad from CMG delivered an enlightening session titled “Scientific and Evidence-Based Advancements in Enhancing Self-Care through Complementary Medicine,” highlighting the advantages of these vital nutrients.
The Multifaceted Role of Vitamin K2 (MenaQ7®) in Cardiovascular, Bone Health, and Beyond
MenaQ7® is crucial for cardiovascular and bone health. It plays a pivotal role in blood coagulation by facilitating the production of prothrombin and other coagulation factors. Additionally, Vitamin K2 helps prevent the accumulation of calcium in blood vessel walls, thereby reducing arterial stiffness. In terms of bone health, it is involved in the production, activation, and carboxylation of osteocalcin, which is essential for calcium transport, homeostasis, and bone mineralization. Recent research has also highlighted its diverse functions, including energy metabolism, antioxidant properties, anti-inflammatory effects, immunomodulation, and brain signaling. These findings suggest potential benefits for conditions such as rheumatoid arthritis, depression in women with PCOS, and Alzheimer’s disease.
Unlocking the Power of Active Folate (Quatrefolic®) for Enhanced Cellular Function and Health
Active Folate (Quatrefolic®) is the biologically active form of folate, crucial for various cellular processes, including one-carbon metabolism, methylation, and DNA repair. Deficiency can lead to anemia, neuropathy, cardiovascular diseases, and cognitive issues. Quatrefolic® is particularly beneficial for those with an MTHFR polymorphism, as it does not require conversion, ensuring optimal utilization.
The Innovation Day was a great success, offering a platform to highlight the advancements and benefits of our premium ingredients, Vitamin K2 (MenaQ7®) and Active Folate (Quatrefolic®). We take pride in supporting the complementary medicine industry with our scientifically proven products, promoting self-care and wellness.
Andrea Fuso, PhD, a 15-year research collaborator with focusing on cognitive health, has expanded his area of study to include Vitamin K2 in neurological support and has published highlighting K2’s role in neurological protection.
Andrea Fuso, PhD, a 15-year research collaborator with Gnosis by Lesaffre focusing on cognitive health, has expanded his area of study to include Vitamin K2 in neurological support and has published a new study highlighting K2’s role in neurological protection.
In the new study [1], Dr. Fuso, Associate Professor in Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine, Sapienza University of Rome, examined K2 as menaquinone-7 (in a reduced form) along with K2 menaquinone-4 on a model of neuroblastoma cells to determine how forms of K2 affect the expression of genes involved in neurodegeneration and neuroinflammation.
Vitamin K2 administration was found to support neurological function by creating a favorable balance of activity: it reduces the expression of genes associated with neurodegeneration (PSEN1 and BACE1) and neuroinflammation (IL-1β and IL-6), while simultaneously upregulating genes protecting against amyloid formation (ADAM10 and ADAM17).
Additionally, the team also profiled the DNA methylation patterns of the genes and discovered a correlation between hypermethylation and the downregulation of PSEN1, IL-1β, and IL-6.
This new mechanistic study supports earlier work discussing K2’s roles in Alzheimer’s via gut dysbiosis.[2]
An expert in neurological research, Fuso’s earlier research with Gnosis illuminated the crucial role of one-carbon metabolism in brain health, influencing gene activity. He demonstrated in vivo that S-Adenosyl-Methionine (SAMe) improves memory [3] and is effective in repressing genes associated with neurodegeneration and reducing amyloid deposition [4]. His study with Adonat® Premium SAMe shows promise for cognitive decline, emphasizing the importance of epigenetic memory and methyl-donor availability for healthy aging, supporting the role of one-carbon metabolism in cognitive decline.
Summarizing his research, Dr. Fuso commented, “Our earlier studies highlighted the role of B vitamins and SAMe as dietary factors connecting nutrition with the epigenetic modulation of brain disease. Now, we introduce research on a new compound crucial for cognition: Vitamin K2”.
“Our 15-year collaboration with Dr. Fuso and his team has resulted in a growing body of evidence demonstrating how ingredients of natural origin [e.g., SAMe and vitamin K2 (as MK-7)] significantly impact the function of the brain and cognitive activity” , says Jean-François Jeanne, Substantiation and Applications Manager at Gnosis by Lesaffre. “We are excited to continue our relationship and support Dr. Fuso’s further research exploring Vitamin K2 for cognitive benefits.”
Our K2 Brochure breaks down the key differences between K1 and K2, explaining their mechanisms of action and the prevalence of deficiency in the population. Including compelling graphic design and messaging, it equips you with the tools to tell the important K2 story in a way that resonates with your audience.
As MenaQ7® K2 has solidified its clinical foundation in supporting strong bone and heart health, consumer awareness is on the rise. While this is excellent news, it also attracts less experienced K2 suppliers to the market. How do you ensure you’re selecting the best K2?
We are thrilled to bring you our Vitamin K2 Brochure, which provides all the insights you need to make a sound ingredient selection. It also equips you with essential elements to craft a compelling story about the importance and benefits of clinically proven MenaQ7®.
The Basics of Vitamin K and Beyond
When considering vitamin K for your product, it’s crucial to understand the distinction between its various forms, primarily K1 and K2. Your product’s effectiveness depends on featuring the most optimal form.
Our K2 Brochure breaks down the key differences between K1 and K2, explaining their mechanisms of action and the prevalence of deficiency in the population. Including compelling graphic design and messaging, it equips you with the tools to tell the important K2 story in a way that resonates with your audience.
What is the Target Audience for K2?
Proven effective in supporting bone and cardiovascular health — foundational across all life stages — Vitamin K2 can be strategically positioned to diverse demographics.
Whether targeting menopausal women, children’s early development, individuals leading active lifestyles, or those focused on longevity, our research and marketing tools offer invaluable support for your communication efforts.
Natural and Pure K2: For the Health of People and Planet
Crafted in the heart of Europe within our cGMP facility, our multi-step fermentation process mirrors nature’s own K2 production. Gain insight into our environmental management systems and the specific measures and commitments Gnosis has implemented to minimize our environmental footprint.
These factors distinguish MenaQ7® from newer market entrants, offering consumers a cherished value: natural, pure, and proven K2.
Clinically Proven MenaQ7® in a Wide Range of Applications
While MenaQ7® is the most clinically proven K2 as MK7 in the market, our efforts to substantiate new areas of importance are underway. Our developments allow you to stay one step ahead of the curve when it comes to clinical research, but also when it comes to innovative delivery systems. Our solutions platform caters to a wide range of finished products.
MenaQ7® is the K2 for brands that aspire for more – and this Brochure tells you why.