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Knapen et al. published the first double-blind, randomized, intervention trial where the results confirm that Vitamin K2 intake is linked to cardiovascular risk. Researchers found that, after three years of daily supplementation with 180 mcg Vitamin K2 as MK-7 (as MenaQ7®), it not only inhibited age-related stiffening of the artery walls, but also made a statistically significant improvement of vascular elasticity, especially in women having high arterial stiffness. To date, the effects of increased menaquinone intake on markers of vascular health have been investigated using predominantly food supplements. Therefore, Knapen et al. sought to study the effects of a menaquinone-fortified yogurt drink (as MenaQ7®) on vitamin K status and markers of vascular health in healthy men and postmenopausal women. Results showed MK-7 was efficiently absorbed from the fortified yogurt drink, improving vitamin K status, which contributed to improved cardiovascular health.
Knapen et al. published the first double-blind, randomized, intervention trial where the results confirm that Vitamin K2 intake is linked to cardiovascular risk. Researchers found that, after three years of daily supplementation with 180 mcg Vitamin K2 as MK-7 (as MenaQ7®), it not only inhibited age-related stiffening of the artery walls, but also made a statistically significant improvement of vascular elasticity, especially in women having high arterial stiffness.
To date, the effects of increased menaquinone intake on markers of vascular health have been investigated using predominantly food supplements. Therefore, Knapen et al. sought to study the effects of a menaquinone-fortified yogurt drink (as MenaQ7®) on vitamin K status and markers of vascular health in healthy men and postmenopausal women. Results showed MK-7 was efficiently absorbed from the fortified yogurt drink, improving vitamin K status, which contributed to improved cardiovascular health.
MenaQ7® products align with clean label principles: providing a pure, active ingredient with few natural inerts like oils and powders
MenaQ7® Solutions are developed with a “Better for You” principle :
- Vegan-Friendly • Free from sugar
- Non- GMO Project Verified • Free from gluten
- Certified Kosher & Halal • Free from allergens
- Free from pesticides and toxins
MenaQ7® is produced to meet the most stringent quality assurance measures.
cGMP
MenaQ7® adheres to current Good Manufacturing Practices. GMP describes the conditions and practices that are necessary for the processing, packing, or storage of food to ensure its safety and traceability.
iso22000
This International Standard specifies the requirements for a food safety management system that combines the following recognized 4 key elements to ensure food safety along the food chain, up to the point of final consumption:
- Interactive communication;
- System management;
- Prerequisite programmes; and
- HACCP principles.
Sef-affirmed GRAS
In the U.S., MenaQ7® is Generally Recognized as Safe (GRAS), a designation by the U.S. Food and Drug Administration (FDA) stating that all necessary research, including the formation of an expert panel to review safety concerns, has been performed.
Non GMO
In the U.S., MenaQ7® is Generally Recognized as Safe (GRAS), a designation by the U.S. Food and Drug Administration (FDA) stating that all necessary research, including the formation of an expert panel to review safety concerns, has been performed.
Novel Food
Novel Food is defined as food that has not been consumed to a significant degree by humans in the EU prior to 1997, when the first Regulation on novel food came into force. ‘Novel Food’ can be newly developed, innovative food or food produced using new technologies and production processes, as well as food traditionally eaten outside of the EU.
Halal
MenaQ7® products are not made form ingredients derived from animals.
Kosher
MenaQ7® is not made from ingredients derived from animals or any non-Kosher plant or fruit part.
Suitable for Vegans and Vegetarians
Products are not manufactured with any raw material or processing aids of animal origin.
The MenaQ7® product range has evolved over the years thanks to the pioneering of new technologies:
MenaQ7®
A Vitamin K2 derived by natural fermentation, completely free from known allergens, backed by published studies demonstrating improvements in bone and cardiovascular health, enabling strong product positioning and differentiation. MenaQ7® is:
- Non-GMO Verified
- Vegan Friendly
- Halal & Kosher Certified
- Gluten Free
- All-transMK-7
With an unquestionable pedigree of clinical validation, MenaQ7® supports strong product positioning and differentiation for industry brands:
- Enable your product to stand out on crowded shelves with a quality, branded ingredient.
- Enjoy the confidence of making structure-function claims based on MenaQ7® K2’s proven benefits.
- Earn Consumer appreciation and loyalty — “Proof That It Works” is the No. 1 consumer selection criteria!
MenaQ7® Matrix
Ensuring the stability of menaquinone ingredients can be complicated as brand owners conceive of more complex formulations. Research shows that moisture and mineral salts are critical variables for degradation, driving the need for a protective technology to shelter the menaquinone molecules during shelf life. Enter MenaQ7® Matrix: the clinically proven health benefits of MenaQ7® delivered via an award-winning Vitamin K2 Matrix protective technology.
This latest innovation is the result of a proprietary technology that protects the particles of MK-7 with no coating, no additives, and no additional ingredients, making it a true clean-label alternative for formulators. It also eases the process of complex formulations, allowing products to hit the market faster while providing cost-effective manufacturing.
MenaQ7® Vitamin K2 as Manaquinone-7 (MK-7) Facts
- Dispersible Formats
- Mineral Combinations
- Liquids
- Chewable Tablets
- Functional Foods
- Tablets
- Soft Gels
For more information on the range of MenaQ7® dilutions and solubilities, and how this comprehensive offer can add value to your finished product :
A steadfast commitment to Vitamin K2 research and development assures MenaQ7® is a superior product based on the following important criteria:
- High Purity
An essential characteristic of a superior Vitamin K2 ingredient is the level of purity, which is important for the overall quality and efficacy of the end product.
Products with a high level of unknowns or impurities offer less of the beneficial effects of the MK-7 molecule. That is not the case with MenaQ7®.
Every batch of MenaQ7® produced is controlled by HPLC.
MenaQ7® purity is defined by:
— High concentration of up to 97% of pure Vitamin K2
— 99,8% of all-trans menaquinone-7 (MK-7)
- All-trans MK-7:
Isomeric purity defines the quality of and speaks to the bioactivity of Vitamin K2 as MK-7. Natural vitamin K in the all-trans configuration , which has been proven to be the biologically active form – meaning that this configuration will activate the carboxylase enzyme, enabling it to further activate proteins like coagulation factors, Osteocalcin, and MGP, among others.
Research has established the efficacity of the trans-form, while the cis–isomers benefit and activity in the body is unknown.
MenaQ7® is an all-trans form of Vitamin K2 as MK-7. Our multistep patented processes successfully deliver nature-identical menaquinone-7.
The diverse MenaQ7® product lines utilize the highest quality, bioactive Vitamin K2 as MK-7 derived by the natural process of fermentation.
- Safety
MenaQ7® materials are given Novel Food status by the European Food Safety Authority (EFSA). The scientific safety evaluation performed by EFSA is a solid confirmation to the public that the product is safe and beneficial.
MenaQ7® is also self-affirmed GRAS (generally recognized as safe) in the United States, a designation by the U.S. Food and Drug Administration (FDA) stating that all necessary research, including the formation of an expert panel to review safety concerns, has been performed.
Recommended daily intake of vitamin K is 120 mcg/day (US) for men, 90 mcg/day (US) for women, and 30-55 mcg/day (US) for children.
A dose and safety study done by Theuwissen et al (2012), showed that extra intake of MK-7, as MenaQ7®, at nutritional doses around RDI improved the activation of proteins like Osteocalcin and Matrix Gla. No adverse effects of thrombin was observed.
NOTE: Vitamin K is needed for proper activation of several coagulation (blood-clotting) proteins, which is why it is recommended that patients receiving oral-anticoagulant (OAC) treatment do not take MK-7 supplements without consulting with their medical doctor.
MenaQ7® is the Optimal Vitamin K2
MenaQ7® Vitamin K2 was created from a desire to substantially impact people’s health through all stages in life. Years of clinical research have established safe and effective health benefits, and these findings have been validated, published in respected peer-reviewed journals. Still today, all industry claims for Vitamin K2 as MK-7’s bone health benefits in children and adults and cardiovascular health benefits in adults stem solely from the clinical validation of MenaQ7®.
The most sought-after Consumer Selection Criteria sets MenaQ7® Vitamin K2 apart from competing K2 brands – “Proof that it works.”
MenaQ7® is the most clinically validated, patented Vitamin K2 as MK-7 available on the market today. Meeting the demands of an increasingly growing global market for health solution products, MenaQ7® varieties are suitable for vegans and vegetarians, free from gluten, dairy, soy, and other known allergens.
Since MenaQ7® was first introduced, novel technologies have been pioneered to expand the product portfolio. Today, the MenaQ7® natural product range caters to a growing global demand for high-purity, stable, and well-researched Vitamin K2 as MK-7. Our Advanced Solutions Platform enables the proven benefits of MenaQ7® to be delivered in a wide range of finished product dose forms, ranging from traditional tablets to in-demand liquids and gummies, and much more. In addition, the stringent quality assurance standards required for MenaQ7® production has earned it the industry’s highest certifications.
MenaQ7® Vitamin K2 as Menaquinone-7 (MK-7) Facts
- MenaQ7®, Vitamin K2 as menaquinone-7 (MK-7), is the most bioavailable, longest-lasting, and most bioactive form of Vitamin K.
- MenaQ7® is the most clinically proven Vitamin K2, with more than 22 human trials, having shaped the Vitamin K2 market of today
- The versatility of its portfolio makes MenaQ7® not only the perfect natural Vitamin K2 for consumer’s health but also for wide formulations & application choices.
Vitamin K-insufficient diets put children at risk of not optimizing their ability to grow strong bones and, potentially, a well-functioning cardiovascular system later in life.
Bones grow and develop most intensively during childhood and adolescence, with up to 90 percent of peak bone mass acquired by age 18 in girls and by age 20 in boys. Without adequate vitamin K to activate Osteocalcin, calcium cannot be properly used to build healthy, strong bones. Population-based studies and clinical trials have tightly linked better K vitamin status in children (meaning higher levels of K vitamins found in blood serum) to achieving strong, healthy bones. Yet a 2014 study of 42 children and 68 adults showed that levels of the bone-building vitamin-K dependent protein osteocalcin are 8-10 times higher in children than adults, hence their requirement of vitamin K is also higher.
But recent research has shown that most children are vitamin K deficient, which is likely attributable to the consumption of more processed food, and generally less that is naturally rich in K vitamins. With the average dietary vitamin K intake dropping significantly over the last 50 years, today’s intake is insufficient for optimal bone development, as evidenced by a population-based Minnesota study showing an increase in forearm fractures in children over a similar 30-year period.
Furthermore, clinical observations show that vitamin K-dependent Matrix Gla Protein (MGP) helps inhibit arterial calcification. Certain medical cases show that calcification may begin in childhood. Hence, early supplementation with Vitamin K2 may contribute to the development of healthy cardiovascular systems.
The Difference MenaQ7® Makes in Child Populations
The consumption of more processed food, less vegetables and generally less food naturally rich in K vitamins has resulted in sub-optimal K vitamin intake. This recognition has led experts within this field to strongly recommend foods enriched with Vitamin K2 as an alternative to giving children Vitamin K2 supplements.
However, a 2008 study published in the British Journal of Nutrition revealed that daily supplementation with 45-50 mcg of Vitamin K2 as MK-7 (as MenaQ7®) may support bone needs from early childhood through the lifespan. Monitoring healthy children between 6 and 10 years of age taking 45-50 mcg of MenaQ7® for two years resulted in improved vitamin K status as well as stronger, denser bones.
MenaQ7® is featured in quality products around the globe.
