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The only Vitamin K2 shaped strictly by data confirming true health benefits: MenaQ7®
Being able to say an ingredient is clinically validated takes an overwhelming investment and commitment, which is the exact course that has shaped the MenaQ7® Vitamin K2 as MK-7 on the market today.
Today’s understanding of Vitamin K2 is based solely on MenaQ7®, the source material for more than 22 human clinical trials (with more underway) demonstrating safe, efficacious benefits for human health. And those studies were published in respected peer-reviewed journals:
MenaQ7® and Cardiovascular Health
- Vermeer C and Vik H. Vascular Diseases and Therapeutics. 2020
- Mansour et al. Journal of the American Society of Hypertension. 2017
- Aoun et al. BMC Nephrology. 2017
- Knapen et al. European Journal of Clinical Nutrition. 2016
- Knapen et al. Journal of Nutritional Science. 2015
- Kurnatowska et al. Polish Archives of Internal Medicine. 2015
- Knapen et al. Thrombosis and Haemostasis. 2015
- Theuwissen et al. British Journal of Nutrition. 2012
- Chatrou et al. Blood Review. 2012
- Dalmeijer et al. Atherosclerosis. 2012
MenaQ7® in Diseased Populations
- Mansour et al. Journal of the American Society of Hypertension. 2017
- Aoun et al. BMC Nephrology. 2017
- Kurnatowska et al. Polish Archive of Internal Medicine, 2015
- Calwue et al. Nephrology Dialysis Transplant. 2014
- Ozdemir et al. Journal Pediatric Hematology Oncology. 2013
- Westenfeld et al. American Journal of Kidney Disease. 2012
MenaQ7® in Healthy Populations and Children’s Health
MenaQ7® for Optimal Bioavailability
This commitment to scientific research and clinical validation has earned MenaQ7® the VitaK2™ Seal of Quality and Efficacy from the world’s leading experts in vitamin K.
MenaQ7® is featured in quality products around the globe.
Knapen et al. published the first double-blind, randomized, intervention trial where the results confirm that Vitamin K2 intake is linked to cardiovascular risk. Researchers found that, after three years of daily supplementation with 180 mcg Vitamin K2 as MK-7 (as MenaQ7®), it not only inhibited age-related stiffening of the artery walls, but also made a statistically significant improvement of vascular elasticity, especially in women having high arterial stiffness. To date, the effects of increased menaquinone intake on markers of vascular health have been investigated using predominantly food supplements. Therefore, Knapen et al. sought to study the effects of a menaquinone-fortified yogurt drink (as MenaQ7®) on vitamin K status and markers of vascular health in healthy men and postmenopausal women. Results showed MK-7 was efficiently absorbed from the fortified yogurt drink, improving vitamin K status, which contributed to improved cardiovascular health.
Knapen et al. published the first double-blind, randomized, intervention trial where the results confirm that Vitamin K2 intake is linked to cardiovascular risk. Researchers found that, after three years of daily supplementation with 180 mcg Vitamin K2 as MK-7 (as MenaQ7®), it not only inhibited age-related stiffening of the artery walls, but also made a statistically significant improvement of vascular elasticity, especially in women having high arterial stiffness.
To date, the effects of increased menaquinone intake on markers of vascular health have been investigated using predominantly food supplements. Therefore, Knapen et al. sought to study the effects of a menaquinone-fortified yogurt drink (as MenaQ7®) on vitamin K status and markers of vascular health in healthy men and postmenopausal women. Results showed MK-7 was efficiently absorbed from the fortified yogurt drink, improving vitamin K status, which contributed to improved cardiovascular health.
MenaQ7® products align with clean label principles: providing a pure, active ingredient with few natural inerts like oils and powders
MenaQ7® Solutions are developed with a “Better for You” principle :
- Vegan-Friendly • Free from sugar
- Non- GMO Project Verified • Free from gluten
- Certified Kosher & Halal • Free from allergens
- Free from pesticides and toxins
MenaQ7® is produced to meet the most stringent quality assurance measures.
cGMP
MenaQ7® adheres to current Good Manufacturing Practices. GMP describes the conditions and practices that are necessary for the processing, packing, or storage of food to ensure its safety and traceability.
iso22000
This International Standard specifies the requirements for a food safety management system that combines the following recognized 4 key elements to ensure food safety along the food chain, up to the point of final consumption:
- Interactive communication;
- System management;
- Prerequisite programmes; and
- HACCP principles.
Sef-affirmed GRAS
In the U.S., MenaQ7® is Generally Recognized as Safe (GRAS), a designation by the U.S. Food and Drug Administration (FDA) stating that all necessary research, including the formation of an expert panel to review safety concerns, has been performed.
Non GMO
In the U.S., MenaQ7® is Generally Recognized as Safe (GRAS), a designation by the U.S. Food and Drug Administration (FDA) stating that all necessary research, including the formation of an expert panel to review safety concerns, has been performed.
Novel Food
Novel Food is defined as food that has not been consumed to a significant degree by humans in the EU prior to 1997, when the first Regulation on novel food came into force. ‘Novel Food’ can be newly developed, innovative food or food produced using new technologies and production processes, as well as food traditionally eaten outside of the EU.
Halal
MenaQ7® products are not made form ingredients derived from animals.
Kosher
MenaQ7® is not made from ingredients derived from animals or any non-Kosher plant or fruit part.
Suitable for Vegans and Vegetarians
Products are not manufactured with any raw material or processing aids of animal origin.
The MenaQ7® product range has evolved over the years thanks to the pioneering of new technologies:
MenaQ7®
A Vitamin K2 derived by natural fermentation, completely free from known allergens, backed by published studies demonstrating improvements in bone and cardiovascular health, enabling strong product positioning and differentiation. MenaQ7® is:
- Non-GMO Verified
- Vegan Friendly
- Halal & Kosher Certified
- Gluten Free
- All-transMK-7
With an unquestionable pedigree of clinical validation, MenaQ7® supports strong product positioning and differentiation for industry brands:
- Enable your product to stand out on crowded shelves with a quality, branded ingredient.
- Enjoy the confidence of making structure-function claims based on MenaQ7® K2’s proven benefits.
- Earn Consumer appreciation and loyalty — “Proof That It Works” is the No. 1 consumer selection criteria!
MenaQ7® Matrix
Ensuring the stability of menaquinone ingredients can be complicated as brand owners conceive of more complex formulations. Research shows that moisture and mineral salts are critical variables for degradation, driving the need for a protective technology to shelter the menaquinone molecules during shelf life. Enter MenaQ7® Matrix: the clinically proven health benefits of MenaQ7® delivered via an award-winning Vitamin K2 Matrix protective technology.
This latest innovation is the result of a proprietary technology that protects the particles of MK-7 with no coating, no additives, and no additional ingredients, making it a true clean-label alternative for formulators. It also eases the process of complex formulations, allowing products to hit the market faster while providing cost-effective manufacturing.
MenaQ7® Vitamin K2 as Manaquinone-7 (MK-7) Facts
- Dispersible Formats
- Mineral Combinations
- Liquids
- Chewable Tablets
- Functional Foods
- Tablets
- Soft Gels
For more information on the range of MenaQ7® dilutions and solubilities, and how this comprehensive offer can add value to your finished product :
A steadfast commitment to Vitamin K2 research and development assures MenaQ7® is a superior product based on the following important criteria:
- High Purity
An essential characteristic of a superior Vitamin K2 ingredient is the level of purity, which is important for the overall quality and efficacy of the end product.
Products with a high level of unknowns or impurities offer less of the beneficial effects of the MK-7 molecule. That is not the case with MenaQ7®.
Every batch of MenaQ7® produced is controlled by HPLC.
MenaQ7® purity is defined by:
— High concentration of up to 97% of pure Vitamin K2
— 99,8% of all-trans menaquinone-7 (MK-7)
- All-trans MK-7:
Isomeric purity defines the quality of and speaks to the bioactivity of Vitamin K2 as MK-7. Natural vitamin K in the all-trans configuration , which has been proven to be the biologically active form – meaning that this configuration will activate the carboxylase enzyme, enabling it to further activate proteins like coagulation factors, Osteocalcin, and MGP, among others.
Research has established the efficacity of the trans-form, while the cis–isomers benefit and activity in the body is unknown.
MenaQ7® is an all-trans form of Vitamin K2 as MK-7. Our multistep patented processes successfully deliver nature-identical menaquinone-7.
The diverse MenaQ7® product lines utilize the highest quality, bioactive Vitamin K2 as MK-7 derived by the natural process of fermentation.
- Safety
MenaQ7® materials are given Novel Food status by the European Food Safety Authority (EFSA). The scientific safety evaluation performed by EFSA is a solid confirmation to the public that the product is safe and beneficial.
MenaQ7® is also self-affirmed GRAS (generally recognized as safe) in the United States, a designation by the U.S. Food and Drug Administration (FDA) stating that all necessary research, including the formation of an expert panel to review safety concerns, has been performed.
Recommended daily intake of vitamin K is 120 mcg/day (US) for men, 90 mcg/day (US) for women, and 30-55 mcg/day (US) for children.
A dose and safety study done by Theuwissen et al (2012), showed that extra intake of MK-7, as MenaQ7®, at nutritional doses around RDI improved the activation of proteins like Osteocalcin and Matrix Gla. No adverse effects of thrombin was observed.
NOTE: Vitamin K is needed for proper activation of several coagulation (blood-clotting) proteins, which is why it is recommended that patients receiving oral-anticoagulant (OAC) treatment do not take MK-7 supplements without consulting with their medical doctor.
MenaQ7® is the Optimal Vitamin K2
MenaQ7® Vitamin K2 was created from a desire to substantially impact people’s health through all stages in life. Years of clinical research have established safe and effective health benefits, and these findings have been validated, published in respected peer-reviewed journals. Still today, all industry claims for Vitamin K2 as MK-7’s bone health benefits in children and adults and cardiovascular health benefits in adults stem solely from the clinical validation of MenaQ7®.
The most sought-after Consumer Selection Criteria sets MenaQ7® Vitamin K2 apart from competing K2 brands – “Proof that it works.”
MenaQ7® is the most clinically validated, patented Vitamin K2 as MK-7 available on the market today. Meeting the demands of an increasingly growing global market for health solution products, MenaQ7® varieties are suitable for vegans and vegetarians, free from gluten, dairy, soy, and other known allergens.
Since MenaQ7® was first introduced, novel technologies have been pioneered to expand the product portfolio. Today, the MenaQ7® natural product range caters to a growing global demand for high-purity, stable, and well-researched Vitamin K2 as MK-7. Our Advanced Solutions Platform enables the proven benefits of MenaQ7® to be delivered in a wide range of finished product dose forms, ranging from traditional tablets to in-demand liquids and gummies, and much more. In addition, the stringent quality assurance standards required for MenaQ7® production has earned it the industry’s highest certifications.
MenaQ7® Vitamin K2 as Menaquinone-7 (MK-7) Facts
- MenaQ7®, Vitamin K2 as menaquinone-7 (MK-7), is the most bioavailable, longest-lasting, and most bioactive form of Vitamin K.
- MenaQ7® is the most clinically proven Vitamin K2, with more than 22 human trials, having shaped the Vitamin K2 market of today
- The versatility of its portfolio makes MenaQ7® not only the perfect natural Vitamin K2 for consumer’s health but also for wide formulations & application choices.