D3 & K2: Better Together for Bone Health
Low Vitamin K and D status is correlated with poor bone quality and higher fracture risk, as shown in many observational studies.
Vitamin D promotes the production of vitamin K-dependent protein osteocalcin, which is responsible for building bone. Yet, when combined with Vitamin K2, osteocalcin levels are significantly increased. [1] Further, Vitamin D supports calcium absorption from the diet, but it needs help from Vitamin K2 to make the bone-building protein osteocalcin active in the body, enabling calcium to bind to the bone matrix, leading to stronger bones.
The combination of MenaQ7® Vitamin K2 and D3 is clinically proven to have beneficial effect on children’s bone health, and MenaQ7® is the only Vitamin K2 as MK-7 proven to deliver on the promise of strong bone health in children and adults. [2]
[1] Koshihara Y et al. J Bone Miner Res. 1993 May;8(5):553-65.
[2] Knapen MHJ et al. Osteoporos Int. 2013 Sep;24(9):2499-507.
D3 with K2 Benefits are Evident Across All Stages of Life
D3 & K2: Better Together for Bone and Heart Health
Matrix Gla Protein (MGP) is the most potent inhibitor of vascular calcification known to date, but it requires Vitamin D to be synthesized. However, MGP is also a K-dependent protein, so it also needs Vitamin K2 to become active, enabling it to actively stop calcium from depositing in the vasculature and other soft tissues.
The combination of MenaQ7® Vitamin K2 and D3 is clinically proven to have cardiovascular benefits, compared to vitamin D3 alone, and confirm their synergistic effect on cardiovascular health. Deficiency, or suboptimal levels of K2 may result in inactive MGP, which is associated with soft tissue calcification.
Other features where vitamin D and K overlap in creating synergies for health are their ability to regulate inflammation and oxidative stress markers and may therefor support the immune system.
