Efficacy

MK-7 is much more effective than MK-4 at doses that do not exceed the present recommended intake for vitamin K. MK-4 has to be applied in very high pharmacological doses (milligrams) to demonstrate benefits for bone and heart health. In case of MK-7, doses in micrograms – 1000x less - are sufficient for significant bioactive effect.

Chart presenting applied doses of various menaquinones: MK-4 and MK-7

45mcg/daily of MK-7 is proven to be sufficient in order to increase the carboxylation process and the activation of vitamin K- dependent proteins such as osteocalcin for bone health and MGP for heart health.